Grace Gifford was born in Dublin in March 1888. She studied art in Dublin and London.

In 1915 Grace began a courtship with the editor of The Irish Review, Joseph Plunkett and they planned to marry. Unknown to Grace, Joseph was a founder of the Irish Volunteers who were planning a rebellion in Dublin.

By the end of Easter Week April 1916 the rebels had surrendered and were imprisoned in Kilmainham Gaol. The leaders were condemned to death by firing squad. When Joseph learned that his execution was scheduled to take place, he sought permission to be married. On the 3rd May 1916 at 6.00pm Grace Gifford entered Kilmainham Gaol. With a priest and two witnesses present she married Joseph. He was executed the next day.

In the aftermath of the Rising, Grace became a member of the Sinn Féin executive. She continued to use her artistic skills to promote Sinn Féin policies and for propaganda purposes during the War of Independence.
Along with the other 1916 widows, Grace was against the Anglo-Irish Treaty. She was arrested in February 1923 and held in Kilmainham Gaol. Following the Civil War, Grace continued to earn a living with her drawings.

Grace Gifford Plunkett died in Dublin on 13th December 1955 and was buried in Glasnevin cemetery.